Bioavailability Studies

Since its inception, EMINENT’s team of research scientists has specialized in conducting bioavailability and bioequivalence testing for small molecules. This critical analysis helps determine how drugs, once ingested orally, are absorbed from the gastrointestinal tract and transported via the systemic circulation to their targeted site of action.

Bioavailability is a crucial measurement in pharmacokinetics, assessed by evaluating the concentration of the active pharmaceutical ingredient (API) in the systemic circulation or at the site where the drug exerts its action. Additionally, the concentration of the API provides insights into the release, absorption, distribution, metabolism, and excretion of the drug compounds.

The assessment of drug bioavailability relies heavily on three primary pharmacokinetic variables: 

• The maximum concentration of the drug in the systemic circulation
• The time taken to reach this maximum concentration, and 
• The area under the curve (AUC), which represents the total drug concentration over time.